01
What is the exact type, subtype, and stage of my cancer?Knowing the histology, grade, and molecular subtype is essential for treatment planning.
02
Has my tumor been tested for actionable biomarkers?Ask about PD-L1, MSI, TMB, and specific gene mutations like KRAS, EGFR, or BRAF.
03
Should I get a second pathology review?Pathology errors happen — especially in rare cancers. Major cancer centers offer second-opinion reviews.
04
What imaging or tests still need to be done for full staging?Complete staging affects whether surgery, radiation, or systemic therapy is recommended first.
05
What are my treatment options, and which do you recommend?Understand the rationale — is this based on NCCN guidelines, institutional preference, or clinical data?
06
What is the goal of this treatment — cure, control, or palliation?This shapes your expectations, side-effect tolerance, and decision framework.
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07
What are the most common side effects and how will they be managed?Ask about acute vs. long-term effects, dose modifications, and supportive medications.
08
How will we know if the treatment is working?Response is typically measured by imaging, lab markers, or symptom assessment at defined intervals.
09
What happens if this treatment doesn't work?Understanding second- and third-line options helps you plan and reduces anxiety about next steps.
10
Should I have comprehensive genomic profiling (e.g., FoundationOne, Tempus)?These tests identify targetable mutations, fusions, and amplifications that could unlock additional therapies.
11
What does my TMB and MSI status mean for immunotherapy eligibility?TMB-High and MSI-High tumors may respond to checkpoint inhibitors like pembrolizumab.
12
Are there any hereditary cancer syndromes I should be tested for?BRCA1/2, Lynch syndrome, Li-Fraumeni, and others may affect treatment and family screening.
13
Can liquid biopsy (ctDNA) be used to monitor my treatment response?Blood-based genomic testing can detect minimal residual disease and emerging resistance mutations.
14
Are there clinical trials available for my specific cancer and biomarker profile?Trials are not a "last resort" — many offer access to cutting-edge therapies early in treatment.
15
Would a molecular tumor board review help identify additional options?Multidisciplinary teams can often find personalized strategies beyond standard-of-care protocols.
16
Can I get a second opinion from an NCI-designated cancer center?Major centers often see rare subtypes and have access to trials not available elsewhere.
17
What supportive care services are available to me?Ask about nutrition, pain management, palliative care, social work, and mental health support.
18
Should I preserve fertility before starting treatment?Certain chemo and radiation regimens can affect fertility — discuss options before starting therapy.
19
What lifestyle modifications can support my treatment outcomes?Exercise, nutrition, sleep, and stress management all have evidence behind them in oncology.
20
What does my long-term survivorship plan look like?Surveillance schedules, late-effect monitoring, and follow-up imaging are critical after treatment ends.
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